Cation-mediated conformational variants of surfactant protein A
نویسندگان
چکیده
منابع مشابه
The Significance and Impacts of Protein Disorder and Conformational Variants
Protein disorder is a topic worth attention from the structural bioinformatics community largely for the technical challenges it presents to the field, but also for its biological and functional implications. The success of structural genomic efforts using X-ray crystallography depends on overcoming several potential bottlenecks (Chapter 40), one ofwhich is the formation of protein crystals tha...
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Surfactant proteins (SP)-A and SP-D have been shown to affect the functions of a variety of innate immune cells and to interact with various immune proteins such as complement and immunoglobulins. The goal of the current study is to test the hypothesis that SP-A regulates IgG-mediated phagocytosis by neutrophils, which are major effector cells of the innate immune response that remove invading ...
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Loss of activity through aggregation and surface-induced denaturation is a significant problem in the production, formulation and administration of therapeutic proteins. Surfactants are commonly used in upstream and downstream processing and drug formulation. However, the effectiveness of a surfactant strongly depends on its mechanism(s) of action and properties of the protein and interfaces. S...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 1999
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(98)00057-x